Omalizumab in the treatment of severe allergic (IgE-mediated) asthma: an update on recent developments

نویسندگان

  • Marc Humbert
  • Janice Canvin
  • Tamara Kiechle
  • Phil Lowe
  • Veit Erpenbeck
چکیده

Omalizumab (OMA), a humanized anti-immunoglobulin E (IgE) monoclonal antibody was approved in the EU in 2005 as an add-on therapy for patients with severe persistent allergic asthma (AA). We present an overview of recent developments in the use of OMA for this indication. Approval for pediatric use: followed the completion of two clinical trials in children 6 to <12 years of age with moderate-to-severe AA, who were either wellor inadequately controlled with inhaled corticosteroids (CS). Pooled analysis of these data demonstrated the efficacy and safety of OMA and led to approval in the EU for use in this population.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2013